Narjes sadat Borghaee; MohammadReza Rabiee
Volume 15, Issue 2 , July and August 2008, , Pages 110-115
Abstract
Background and purpose: Preeclampsia is one of the hypertensive diseases of pregnancy with extraordinary significance in maternal and fetal health which is the most important maternal mortality cause in developing couutries (20% to 80%). Ethnicity is also one of the factors in preclampsia. Therefore ...
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Background and purpose: Preeclampsia is one of the hypertensive diseases of pregnancy with extraordinary significance in maternal and fetal health which is the most important maternal mortality cause in developing couutries (20% to 80%). Ethnicity is also one of the factors in preclampsia. Therefore due to the high prevalence of preeclampsia in Dezyani Center in Gorgan Iran (5.7%) and co-existence of various ethnic residents the present study was designed to determine the effect of ethnicity on the incidence of preeclampsia. Methods and materials: This case-control study involued the population of pregnant women admitted in Dezyani center Iran. Cases and controls were homogeneous as far as employment marital status spouse's job residential location gravidity and maternal age were concerred. Cases with preeclampsia symptoms were purposively selected. In total 500 subjects (250 cases and 250 controls) participated in the study. Questionnaires were filled out via interview and checklists were completed on the basis of laboratory tests of blood and urine. The obtained data were analyzed in SPSS using Chi-square t-test and Mann Whitney U test. Results: In cases of urinary infection probability of preeclampsia increased 1.77 times (CI=95% odds ratio=1.77) which did not relate to cases' ethnicity. However if urinary infection is excluded preeclampsia can be related to ethnicity. Conclusion: The results indicated that Turkmen and Sistani ethnic groups were predisposed to preeclampsia.
N MEFTAH; MR RABIEI; GHR ROUSHANDEL; S BESHARAT; A JABARI; SH SEMNANI; R AZARHOUSH; N ABDOLLAHI
Volume 13, Issue 2 , July and August 2006, , Pages 74-79
Abstract
Background and Purpose: P53 gene is a tumor suppressive gene and its product, P53 protein, is a protective factor against tumor formation that inhibits the extension of genetically damaged cells. P53 aggregation in tumoral cell nucleus is related with p53 gene mutations, which can be detected by immunohistochemical ...
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Background and Purpose: P53 gene is a tumor suppressive gene and its product, P53 protein, is a protective factor against tumor formation that inhibits the extension of genetically damaged cells. P53 aggregation in tumoral cell nucleus is related with p53 gene mutations, which can be detected by immunohistochemical methods. This study was designed to investigate the protein aggregation in patients with gastric cancer in Gorgan, Iran.
Methods and materials: All paraffin-embedded blocks of gastric cancer cases during the years 2000 to 2004 in the pathology ward of the 5th Azar Hospital in Gorgan, Iran (111 cases altogether) were evaluated and stained, for detecting microtome cutting. The obtained data were entered into SPSS and chi-square was used for analysis.
Results: 111 cases with gastric cancer were investigated. The most frequent type of gastric tumor was adenocarcinoma (66.7%). In 59.5% of the affected cases, P53 protein was detected. No significant relationship was observed between P53 expression and factors such as age, gender, and histological type of the tumor.
Conclusions: In this study, P53 protein rate was high but it showed no significant relationship with other variables. We suggest further studies to discover the relationship between protein aggregation in tumor cells and other variables in affected cases.